Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3429352..3430009 Replicon chromosome
Accession NZ_LR134235
Organism Klebsiella variicola strain NCTC9668

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EL159_RS17120 Protein ID WP_002916310.1
Coordinates 3429599..3430009 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EL159_RS17115 Protein ID WP_002916312.1
Coordinates 3429352..3429618 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL159_RS17095 3425795..3426523 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
EL159_RS17100 3426574..3426885 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
EL159_RS17105 3427049..3427708 + 660 WP_008806429.1 hemolysin III family protein -
EL159_RS17110 3428123..3429106 - 984 WP_012967246.1 tRNA-modifying protein YgfZ -
EL159_RS17115 3429352..3429618 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EL159_RS17120 3429599..3430009 + 411 WP_002916310.1 protein YgfX Toxin
EL159_RS17125 3430016..3430537 - 522 WP_008806427.1 flavodoxin FldB -
EL159_RS17130 3430638..3431534 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
EL159_RS17135 3431557..3432270 + 714 WP_064166672.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL159_RS17140 3432276..3434009 + 1734 WP_064166671.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T287254 WP_002916310.1 NZ_LR134235:3429599-3430009 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT287254 WP_002916312.1 NZ_LR134235:3429352-3429618 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References