Detailed information of TA system TA287250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2237622..2239303
• Replicon: chromosome
• Accession: NZ_LR134235
• Organism: Klebsiella variicola strain NCTC9668

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: EL159_RS11210
• Protein ID: WP_040971114.1
• Coordinates: 2237622..2238539 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A223UHG0
• Locus tag: EL159_RS11215
• Protein ID: WP_040971113.1
• Coordinates: 2238545..2239303 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL159_RS11190	2232928..2234448	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
EL159_RS11195	2234445..2235443	+	999	WP_004206363.1	ribose ABC transporter permease	-
EL159_RS11200	2235474..2236415	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
EL159_RS11205	2236490..2237497	+	1008	WP_022065799.1	carbohydrate kinase family protein	-
EL159_RS11210	2237622..2238539	-	918	WP_040971114.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL159_RS11215	2238545..2239303	-	759	WP_040971113.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
EL159_RS11220	2239388..2240116	-	729	WP_008807258.1	response regulator transcription factor	-
EL159_RS11225	2240389..2242536	+	2148	WP_077598908.1	formate dehydrogenase subunit alpha	-
EL159_RS11230	2243154..2243840	+	687	WP_110217328.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34737.11 Da
• Isoelectric Point: 5.4707

>T287250 WP_040971114.1 NZ_LR134235:c2238539-2237622 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDVDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28683.10 Da
• Isoelectric Point: 10.1988

>AT287250 WP_040971113.1 NZ_LR134235:c2239303-2238545 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVMLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A0A223UHG0