Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3794027..3794622 Replicon chromosome
Accession NZ_LR134234
Organism Escherichia coli strain NCTC8623

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag EL131_RS18665 Protein ID WP_000239579.1
Coordinates 3794272..3794622 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag EL131_RS18660 Protein ID WP_001223208.1
Coordinates 3794027..3794278 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL131_RS18650 3789692..3793471 + 3780 WP_126510116.1 autotransporter assembly complex protein TamB -
EL131_RS18655 3793474..3793815 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
EL131_RS18660 3794027..3794278 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
EL131_RS18665 3794272..3794622 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
EL131_RS18670 3794702..3795232 - 531 WP_000055075.1 inorganic diphosphatase -
EL131_RS18675 3795542..3796498 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
EL131_RS18680 3796808..3798310 + 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
EL131_RS18685 3798324..3799346 + 1023 WP_001355798.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T287243 WP_000239579.1 NZ_LR134234:3794272-3794622 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT287243 WP_001223208.1 NZ_LR134234:3794027-3794278 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References