Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1761601..1762226 Replicon chromosome
Accession NZ_LR134234
Organism Escherichia coli strain NCTC8623

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag EL131_RS08655 Protein ID WP_000911329.1
Coordinates 1761601..1761999 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL131_RS08660 Protein ID WP_000450524.1
Coordinates 1761999..1762226 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL131_RS08635 1757479..1757679 + 201 WP_000383836.1 YpfN family protein -
EL131_RS08640 1757789..1758487 - 699 WP_000679812.1 esterase -
EL131_RS08645 1758561..1760576 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
EL131_RS08650 1760591..1761454 - 864 WP_001267507.1 neutral zinc metallopeptidase -
EL131_RS08655 1761601..1761999 - 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL131_RS08660 1761999..1762226 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL131_RS08665 1762380..1763093 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL131_RS08670 1763306..1764340 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL131_RS08675 1764357..1765235 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL131_RS08680 1765381..1765953 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL131_RS08685 1765953..1766423 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T287236 WP_000911329.1 NZ_LR134234:c1761999-1761601 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT287236 WP_000450524.1 NZ_LR134234:c1762226-1761999 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References