Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2213843..2214369 Replicon chromosome
Accession NZ_LR134231
Organism Escherichia coli strain NCTC9087

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL105_RS10790 Protein ID WP_000323025.1
Coordinates 2214082..2214369 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL105_RS10785 Protein ID WP_000534858.1
Coordinates 2213843..2214082 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL105_RS10750 2208957..2209208 + 252 Protein_2085 DUF977 family protein -
EL105_RS10755 2209205..2209561 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EL105_RS22400 2210172..2210459 + 288 Protein_2087 hypothetical protein -
EL105_RS10770 2211228..2212541 + 1314 WP_000589005.1 ISNCY family transposase -
EL105_RS10775 2212978..2213310 - 333 WP_001301033.1 protein FlxA -
EL105_RS10780 2213513..2213818 - 306 WP_001326990.1 hypothetical protein -
EL105_RS10785 2213843..2214082 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL105_RS10790 2214082..2214369 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL105_RS10795 2214441..2214596 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL105_RS10800 2214813..2215064 + 252 WP_000980994.1 hypothetical protein -
EL105_RS10805 2215131..2215409 + 279 WP_012304870.1 hypothetical protein -
EL105_RS10810 2215411..2216460 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL105_RS10815 2216474..2217226 + 753 WP_001047135.1 antitermination protein -
EL105_RS10820 2217504..2217593 - 90 WP_120795389.1 hypothetical protein -
EL105_RS10825 2217648..2217860 - 213 WP_000087756.1 cold shock-like protein CspF -
EL105_RS10830 2218161..2218376 + 216 WP_000066484.1 cold shock-like protein CspB -
EL105_RS22515 2218740..2218910 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL105_RS10835 2219130..2219345 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2191101..2230122 39021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287217 WP_000323025.1 NZ_LR134231:2214082-2214369 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287217 WP_000534858.1 NZ_LR134231:2213843-2214082 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References