Detailed information of TA system TA028721

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3845278..3845944
• Replicon: chromosome
• Accession: NC_020064
• Organism: Serratia marcescens FGI94

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: L0MIX1
• Locus tag: D781_RS17525
• Protein ID: WP_015673667.1
• Coordinates: 3845278..3845697 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: L0MIU8
• Locus tag: D781_RS17530
• Protein ID: WP_015673668.1
• Coordinates: 3845678..3845944 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D781_RS17505	3841250..3842980	-	1731	WP_015673663.1	single-stranded-DNA-specific exonuclease RecJ	-
D781_RS17510	3842993..3843709	-	717	WP_015673664.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
D781_RS17515	3843737..3844636	-	900	WP_015673665.1	site-specific tyrosine recombinase XerD	-
D781_RS17520	3844728..3845246	+	519	WP_041411867.1	flavodoxin FldB	-
D781_RS17525	3845278..3845697	-	420	WP_015673667.1	protein YgfX	Toxin
D781_RS17530	3845678..3845944	-	267	WP_015673668.1	FAD assembly factor SdhE	Antitoxin
D781_RS17535	3846284..3847276	+	993	WP_015673669.1	tRNA-modifying protein YgfZ	-
D781_RS17540	3847331..3848011	-	681	WP_015673670.1	hemolysin III family protein	-
D781_RS17545	3848206..3848814	+	609	WP_015673671.1	HD domain-containing protein	-
D781_RS17550	3848846..3850165	-	1320	WP_015673672.1	MHS family MFS transporter	-
D781_RS17555	3850162..3850815	-	654	WP_015673673.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16338.28 Da
• Isoelectric Point: 10.9145

>T28721 WP_015673667.1 NC_020064:c3845697-3845278 [Serratia sp. FGI94]
VAQWRCDVRISWRTQLVSLLAHGALILLILISPWPESYDPIWLLLLTLVVFECIRSQTRIASRQGELRLLSAPQRVIWQG
KEWRLARRPWMLRCGMLLTLQASGKRKRRRLWLASDCISSAEWRQLCQRMQLAEDESEG

Nucleotide

• Length: 420 bp

>T28721 NC_020064:c3845697-3845278 [Serratia sp. FGI94]
GTGGCCCAGTGGCGATGTGATGTCCGCATCTCCTGGCGTACTCAGCTTGTCTCGTTGTTGGCGCATGGCGCGCTGATACT
GCTGATTCTGATCTCGCCGTGGCCGGAGAGTTACGACCCGATCTGGCTGCTGCTGCTGACGCTGGTGGTTTTCGAATGTA
TTCGCAGTCAGACGCGTATTGCTTCGCGTCAGGGAGAGCTGCGTCTGCTTTCCGCGCCGCAGCGGGTAATTTGGCAGGGC
AAGGAGTGGCGGCTGGCCCGCCGCCCCTGGATGCTGCGCTGCGGTATGCTGCTGACGCTGCAGGCGAGCGGCAAACGCAA
ACGCCGCCGGCTGTGGCTGGCGTCGGACTGTATCAGCAGCGCCGAGTGGCGGCAGTTGTGCCAGCGGATGCAGCTGGCCG
AGGATGAGTCTGAAGGCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10377.85 Da
• Isoelectric Point: 5.0717

>AT28721 WP_015673668.1 NC_020064:c3845944-3845678 [Serratia sp. FGI94]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDDKALFVRLLQCDDPDLFNWLMNHGAPQDAELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT28721 NC_020064:c3845944-3845678 [Serratia sp. FGI94]
ATGGATATTAATAACAAAGCGCGTATTCACTGGGCTTGCCGCCGGGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATTCATTGAGCGACGACGACAAGGCGCTGTTCGTGCGTCTGTTGCAGTGCGACGATCCTGACC
TGTTTAACTGGCTGATGAATCATGGCGCCCCGCAGGACGCCGAACTGCAGAGAATGGTGACGCTGATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: L0MIX1

Antitoxin

• AlphaFold DB: L0MIU8