Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3660376..3660994 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL118_RS17920 Protein ID WP_001291435.1
Coordinates 3660776..3660994 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL118_RS17915 Protein ID WP_000344800.1
Coordinates 3660376..3660750 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS17905 3655465..3656658 + 1194 WP_097516723.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL118_RS17910 3656681..3659830 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL118_RS17915 3660376..3660750 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL118_RS17920 3660776..3660994 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL118_RS17925 3661166..3661717 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL118_RS17930 3661833..3662303 + 471 WP_000136192.1 YlaC family protein -
EL118_RS17935 3662467..3664017 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL118_RS17940 3664059..3664412 - 354 WP_097516724.1 DUF1428 family protein -
EL118_RS17950 3664791..3665102 + 312 WP_000409911.1 MGMT family protein -
EL118_RS17955 3665133..3665705 - 573 WP_097516725.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287203 WP_001291435.1 NZ_LR134228:3660776-3660994 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287203 WP_000344800.1 NZ_LR134228:3660376-3660750 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References