Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2913809..2914335 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL118_RS14270 Protein ID WP_000323025.1
Coordinates 2913809..2914096 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL118_RS14275 Protein ID WP_000534858.1
Coordinates 2914096..2914335 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS14210 2908979..2909329 - 351 WP_000193289.1 YdfR family protein -
EL118_RS14215 2909334..2909549 - 216 WP_000839572.1 class II holin family protein -
EL118_RS14240 2910362..2911051 - 690 WP_001064896.1 antiterminator -
EL118_RS14245 2911048..2911413 - 366 WP_000139992.1 RusA family crossover junction endodeoxyribonuclease -
EL118_RS14250 2911414..2912469 - 1056 WP_024188444.1 DUF968 domain-containing protein -
EL118_RS14255 2912471..2912749 - 279 WP_024175747.1 hypothetical protein -
EL118_RS14260 2913046..2913438 - 393 WP_000737636.1 hypothetical protein -
EL118_RS14265 2913582..2913737 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL118_RS14270 2913809..2914096 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL118_RS14275 2914096..2914335 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL118_RS14280 2914360..2914665 + 306 WP_001326990.1 hypothetical protein -
EL118_RS14285 2914868..2915200 + 333 WP_001317460.1 FlxA-like family protein -
EL118_RS14290 2915637..2916977 - 1341 WP_000589012.1 ISNCY family transposase -
EL118_RS14305 2917678..2918487 + 810 WP_126509240.1 chaperonin -
EL118_RS14310 2918634..2919056 - 423 WP_001151221.1 DUF977 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2886581..2935011 48430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287202 WP_000323025.1 NZ_LR134228:c2914096-2913809 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287202 WP_000534858.1 NZ_LR134228:c2914335-2914096 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References