Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2542354..2542992 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL118_RS12350 Protein ID WP_000813794.1
Coordinates 2542816..2542992 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL118_RS12345 Protein ID WP_001270286.1
Coordinates 2542354..2542770 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS12325 2537506..2538447 - 942 WP_001251304.1 ABC transporter permease -
EL118_RS12330 2538448..2539461 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL118_RS12335 2539479..2540624 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EL118_RS12340 2540869..2542275 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL118_RS12345 2542354..2542770 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL118_RS12350 2542816..2542992 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL118_RS12355 2543214..2543444 + 231 WP_000494244.1 YncJ family protein -
EL118_RS12360 2543536..2545497 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL118_RS12365 2545570..2546106 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
EL118_RS12370 2546159..2547373 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2542354..2559443 17089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287201 WP_000813794.1 NZ_LR134228:c2542992-2542816 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287201 WP_001270286.1 NZ_LR134228:c2542770-2542354 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References