Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2445644..2447232 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL118_RS11935 Protein ID WP_097516869.1
Coordinates 2445910..2447232 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL118_RS11930 Protein ID WP_001301023.1
Coordinates 2445644..2445910 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS11930 2445644..2445910 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL118_RS11935 2445910..2447232 + 1323 WP_097516869.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
EL118_RS11945 2447482..2448468 + 987 Protein_2316 site-specific integrase -
EL118_RS11950 2448484..2449181 - 698 Protein_2317 IS1 family transposase -
EL118_RS11955 2449335..2450285 - 951 WP_000947148.1 magnesium/cobalt transporter CorA -
EL118_RS24375 2450437..2450493 - 57 WP_211180520.1 protein YsgD -
EL118_RS11960 2450655..2450969 + 315 WP_000951129.1 hypothetical protein -
EL118_RS11965 2450998..2451695 + 698 Protein_2321 IS1 family transposase -
EL118_RS11970 2451890..2452036 + 147 Protein_2322 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49146.65 Da        Isoelectric Point: 8.2482

>T287200 WP_097516869.1 NZ_LR134228:2445910-2447232 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQGLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT287200 WP_001301023.1 NZ_LR134228:2445644-2445910 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References