Detailed information of TA system TA028720

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3634967..3635634
• Replicon: chromosome
• Accession: NC_020064
• Organism: Serratia marcescens FGI94

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: L0MIA4
• Locus tag: D781_RS22980
• Protein ID: WP_015673490.1
• Coordinates: 3635305..3635634 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: D781_RS16595
• Protein ID: WP_148285454.1
• Coordinates: 3634967..3635266 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D781_RS16560	3630809..3631243	+	435	WP_015673483.1	hypothetical protein	-
D781_RS16565	3631303..3632142	+	840	WP_015673484.1	hypothetical protein	-
D781_RS16570	3632201..3632392	+	192	WP_041412185.1	hypothetical protein	-
D781_RS16575	3632806..3633627	+	822	WP_015673486.1	DUF945 domain-containing protein	-
D781_RS16580	3633658..3634101	+	444	WP_015673487.1	antirestriction protein	-
D781_RS16585	3634114..3634656	+	543	WP_015673488.1	DNA repair protein RadC	-
D781_RS22975	3634653..3634874	+	222	WP_015673489.1	DUF987 family protein	-
D781_RS16595	3634967..3635266	+	300	WP_148285454.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D781_RS22980	3635305..3635634	+	330	WP_015673490.1	TA system toxin CbtA family protein	Toxin
D781_RS23265	3636057..3636701	+	645	WP_051032600.1	hypothetical protein	-
D781_RS23725	3636775..3637077	+	303	WP_158497487.1	hypothetical protein	-
D781_RS16605	3637090..3637497	+	408	WP_041411858.1	hypothetical protein	-
D781_RS16610	3637593..3637994	-	402	WP_015673491.1	hypothetical protein	-
D781_RS16615	3638177..3638734	-	558	WP_015673492.1	hypothetical protein	-
D781_RS23730	3638742..3639101	-	360	WP_124014456.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3620616..3638734	18118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (4-95)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12380.05 Da
• Isoelectric Point: 8.9981

>T28720 WP_015673490.1 NC_020064:3635305-3635634 [Serratia sp. FGI94]
MQTISSHPTRATQPCQSPVETWQRLLTHLLSQHYGLTLNDTPFSNETAIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T28720 NC_020064:3635305-3635634 [Serratia sp. FGI94]
ATGCAAACCATATCATCACACCCGACACGGGCGACTCAGCCCTGCCAGTCACCCGTTGAAACCTGGCAACGGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACTCCGTTCAGTAATGAAACCGCCATACGAGAGCATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGACCGAAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCGTAGTGGATATTTTGCGAGCAAGGCGCTCTACTGGCTTGCTAAAAACTAA
CGTGAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11047.71 Da
• Isoelectric Point: 5.4758

>AT28720 WP_148285454.1 NC_020064:3634967-3635266 [Serratia sp. FGI94]
VLLPPCFGARLVQEGNRLHFLSDRAGFSGAFAVDFSMRLDQAFPLMMKQLELMLTSGELNPRHPHCVTLYHNGLTCEADT
LGSCGYVYIAIYPEQTEPQ

Nucleotide

• Length: 300 bp

>AT28720 NC_020064:3634967-3635266 [Serratia sp. FGI94]
GTGCTGTTACCCCCCTGTTTTGGTGCCCGTCTGGTACAGGAGGGCAACCGACTGCATTTTCTCTCTGACCGCGCAGGATT
TAGCGGGGCATTTGCCGTCGATTTTTCAATGCGCCTTGACCAGGCATTTCCGTTAATGATGAAGCAACTTGAGCTGATGC
TGACCAGTGGAGAGCTTAACCCTCGCCACCCGCACTGCGTCACGCTTTACCACAATGGGCTCACCTGCGAAGCCGATACA
CTAGGCTCCTGTGGTTATGTCTACATTGCTATCTATCCTGAGCAAACTGAGCCGCAGTAA

Structures

Toxin

• AlphaFold DB: L0MIA4