Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2371185..2371711 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL118_RS11535 Protein ID WP_000323025.1
Coordinates 2371424..2371711 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL118_RS11530 Protein ID WP_000534858.1
Coordinates 2371185..2371424 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS11495 2366371..2366598 + 228 WP_000476993.1 transcriptional regulator -
EL118_RS11500 2366582..2367103 + 522 WP_000705349.1 hypothetical protein -
EL118_RS11505 2367084..2368049 + 966 WP_126509210.1 hypothetical protein -
EL118_RS11510 2368090..2368509 + 420 WP_001151195.1 DUF977 family protein -
EL118_RS11515 2368543..2369883 + 1341 WP_000589012.1 ISNCY family transposase -
EL118_RS11520 2370320..2370652 - 333 WP_001317460.1 FlxA-like family protein -
EL118_RS11525 2370855..2371160 - 306 WP_001326990.1 hypothetical protein -
EL118_RS11530 2371185..2371424 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL118_RS11535 2371424..2371711 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL118_RS11540 2371783..2371938 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL118_RS11545 2372155..2372406 + 252 WP_000980994.1 hypothetical protein -
EL118_RS11550 2372473..2372751 + 279 WP_012304870.1 hypothetical protein -
EL118_RS11555 2372753..2373802 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL118_RS11560 2373816..2374568 + 753 WP_001047135.1 antitermination protein -
EL118_RS11565 2374846..2374935 - 90 WP_120795389.1 hypothetical protein -
EL118_RS11570 2374990..2375202 - 213 WP_000087756.1 cold shock-like protein CspF -
EL118_RS11575 2375503..2375718 + 216 WP_000066484.1 cold shock-like protein CspB -
EL118_RS24365 2376082..2376252 - 171 WP_001405948.1 putative zinc-binding protein YnfU -
EL118_RS11580 2376472..2376687 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2348139..2409735 61596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287199 WP_000323025.1 NZ_LR134228:2371424-2371711 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287199 WP_000534858.1 NZ_LR134228:2371185-2371424 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References