Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1386658..1387283 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL118_RS06745 Protein ID WP_000911330.1
Coordinates 1386885..1387283 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL118_RS06740 Protein ID WP_000450524.1
Coordinates 1386658..1386885 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS06715 1382460..1382930 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
EL118_RS06720 1382930..1383502 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL118_RS06725 1383648..1384526 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL118_RS06730 1384543..1385577 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL118_RS06735 1385790..1386503 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL118_RS06740 1386658..1386885 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL118_RS06745 1386885..1387283 + 399 WP_000911330.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL118_RS06750 1387430..1388293 + 864 WP_001267498.1 neutral zinc metallopeptidase -
EL118_RS06755 1388308..1390323 + 2016 WP_000829336.1 tRNA cytosine(34) acetyltransferase TmcA -
EL118_RS06760 1390397..1391095 + 699 WP_000679812.1 esterase -
EL118_RS06765 1391205..1391405 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T287193 WP_000911330.1 NZ_LR134228:1386885-1387283 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT287193 WP_000450524.1 NZ_LR134228:1386658-1386885 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References