Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1126644..1127170 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL118_RS05460 Protein ID WP_000323025.1
Coordinates 1126883..1127170 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL118_RS05455 Protein ID WP_000534858.1
Coordinates 1126644..1126883 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS05430 1122049..1122675 + 627 WP_000254708.1 protein-L-isoaspartate O-methyltransferase -
EL118_RS05435 1122815..1123933 + 1119 WP_126509153.1 murein hydrolase activator NlpD -
EL118_RS05440 1124002..1125342 + 1341 WP_000589012.1 ISNCY family transposase -
EL118_RS05445 1125779..1126111 - 333 WP_001317460.1 FlxA-like family protein -
EL118_RS05450 1126314..1126619 - 306 WP_001326990.1 hypothetical protein -
EL118_RS05455 1126644..1126883 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL118_RS05460 1126883..1127170 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL118_RS05465 1127333..1128325 + 993 WP_000081550.1 RNA polymerase sigma factor RpoS -
EL118_RS05470 1128419..1129783 - 1365 WP_000104429.1 GntP family transporter -
EL118_RS05475 1129872..1130648 - 777 WP_001136918.1 HPr family phosphocarrier protein -
EL118_RS05480 1130653..1131291 - 639 WP_001278994.1 aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1103635..1127170 23535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287192 WP_000323025.1 NZ_LR134228:1126883-1127170 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287192 WP_000534858.1 NZ_LR134228:1126644-1126883 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References