Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 937022..937676 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag EL118_RS04575 Protein ID WP_000244777.1
Coordinates 937269..937676 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EL118_RS04570 Protein ID WP_000354046.1
Coordinates 937022..937288 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS04550 932991..934424 - 1434 WP_001753034.1 6-phospho-beta-glucosidase BglA -
EL118_RS04555 934469..934780 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
EL118_RS04560 934944..935603 + 660 WP_000250274.1 hemolysin III family protein -
EL118_RS04565 935799..936779 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
EL118_RS04570 937022..937288 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EL118_RS04575 937269..937676 + 408 WP_000244777.1 toxin CptA Toxin
EL118_RS04580 937716..938237 - 522 WP_001055874.1 flavodoxin FldB -
EL118_RS04585 938349..939245 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EL118_RS04590 939270..939980 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL118_RS04595 939986..941719 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T287190 WP_000244777.1 NZ_LR134228:937269-937676 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT287190 WP_000354046.1 NZ_LR134228:937022-937288 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References