Detailed information of TA system TA028719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3192302..3192945
• Replicon: chromosome
• Accession: NC_020064
• Organism: Serratia marcescens FGI94

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: D781_RS14585
• Protein ID: WP_041411835.1
• Coordinates: 3192529..3192945 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: L0MKI5
• Locus tag: D781_RS14580
• Protein ID: WP_015673101.1
• Coordinates: 3192302..3192532 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D781_RS14565	3188326..3190389	-	2064	WP_015673098.1	dimethylglycine demethylation protein DgcA	-
D781_RS14570	3190446..3190976	-	531	WP_015673099.1	4-vinyl reductase	-
D781_RS14575	3191008..3191985	-	978	WP_041411834.1	dipeptidase	-
D781_RS14580	3192302..3192532	+	231	WP_015673101.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D781_RS14585	3192529..3192945	+	417	WP_041411835.1	type II toxin-antitoxin system VapC family toxin	Toxin
D781_RS14590	3192995..3194149	-	1155	WP_015673103.1	GlxA family transcriptional regulator	-
D781_RS14595	3194430..3195806	-	1377	WP_015673104.1	L-serine ammonia-lyase	-
D781_RS14600	3196092..3197747	+	1656	WP_015673105.1	BCCT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14910.29 Da
• Isoelectric Point: 7.8276

>T28719 WP_041411835.1 NC_020064:3192529-3192945 [Serratia sp. FGI94]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHAQLVEAFCSRLDAILPWDRA
AVDETTALKAALAAVGTPIGPNDTAIAGHAIAAGAILVTNNHKEFARVPGLALEDWVA

Nucleotide

• Length: 417 bp

>T28719 NC_020064:3192529-3192945 [Serratia sp. FGI94]
ATGAGCCACACCTACATGCTGGACACCTGTATTTGCTCTTACATTATGCGCGAGCAGCCGGCAGCGGCGATCCGGCGTCT
GGAGCAGGCGGTGATGCAACGCCACCGGATCGTGGTGTCGGCCATTACCTATGCCGAAATGCGCTTTGGTGCGATCGGTA
AAAAGGCCTCACCGCGTCATGCGCAACTGGTCGAGGCCTTCTGCAGCCGCCTTGACGCCATTTTGCCGTGGGACCGCGCC
GCGGTGGATGAAACCACGGCGCTGAAGGCCGCGTTGGCCGCCGTCGGTACGCCGATCGGGCCCAACGATACCGCAATTGC
CGGCCATGCCATCGCCGCCGGCGCCATTCTGGTCACCAATAATCACAAGGAGTTTGCGCGCGTGCCCGGACTGGCGCTGG
AAGACTGGGTGGCATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8704.86 Da
• Isoelectric Point: 4.6182

>AT28719 WP_015673101.1 NC_020064:3192302-3192532 [Serratia sp. FGI94]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIAREGDTIILRPVKPNWGSFLLEDKADADFMTEREDIINDEGRVKP

Nucleotide

• Length: 231 bp

>AT28719 NC_020064:3192302-3192532 [Serratia sp. FGI94]
ATGAGAACAGTATCTGTGTTTAAAAACGGCAATAACCGCGCGATCCGCCTGCCCCGCGATATGGATTTTGCAGGCGTCAA
CGAACTGGAGATCGCCCGTGAAGGCGACACCATCATCCTGCGGCCGGTAAAGCCGAACTGGGGATCGTTCCTGCTGGAAG
ACAAAGCCGATGCGGACTTTATGACGGAACGTGAAGACATCATTAATGACGAGGGACGCGTCAAACCATGA

Structures

Antitoxin

• AlphaFold DB: L0MKI5