Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49114..49946 Replicon chromosome
Accession NZ_LR134228
Organism Escherichia coli strain NCTC9699

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag EL118_RS00250 Protein ID WP_000854753.1
Coordinates 49114..49488 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q5I3J0
Locus tag EL118_RS00255 Protein ID WP_001280951.1
Coordinates 49578..49946 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL118_RS00220 44480..45403 - 924 WP_097516854.1 carboxylate/amino acid/amine transporter -
EL118_RS00225 45514..46698 - 1185 WP_001172876.1 sugar efflux transporter -
EL118_RS00235 47490..48335 - 846 WP_001406222.1 DUF4942 domain-containing protein -
EL118_RS00240 48420..48617 - 198 WP_000839243.1 DUF957 domain-containing protein -
EL118_RS00245 48629..49117 - 489 WP_001549830.1 hypothetical protein -
EL118_RS00250 49114..49488 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
EL118_RS00255 49578..49946 - 369 WP_001280951.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL118_RS00260 50109..50330 - 222 WP_001405861.1 DUF987 domain-containing protein -
EL118_RS00265 50399..50875 - 477 WP_001186724.1 RadC family protein -
EL118_RS00270 50891..51223 - 333 Protein_53 antirestriction protein -
EL118_RS00275 51470..52590 + 1121 WP_087451024.1 IS3-like element ISSen4 family transposase -
EL118_RS00280 53529..54524 - 996 WP_000157595.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T287184 WP_000854753.1 NZ_LR134228:c49488-49114 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13699.56 Da        Isoelectric Point: 7.0268

>AT287184 WP_001280951.1 NZ_LR134228:c49946-49578 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB Q5I3J0

References