Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2900456..2901129 Replicon chromosome
Accession NC_020064
Organism Serratia marcescens FGI94

Toxin (Protein)


Gene name vapC Uniprot ID L0MGK3
Locus tag D781_RS13205 Protein ID WP_015672838.1
Coordinates 2900456..2900896 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L0MGH9
Locus tag D781_RS13210 Protein ID WP_015672839.1
Coordinates 2900893..2901129 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D781_RS13185 2895731..2896594 - 864 WP_015672834.1 protein deglycase HchA -
D781_RS13190 2896733..2897134 - 402 WP_041412140.1 flagellar protein FlhE -
D781_RS13195 2897137..2899218 - 2082 WP_015672836.1 flagellar biosynthesis protein FlhA -
D781_RS13200 2899211..2900362 - 1152 WP_015672837.1 flagellar type III secretion system protein FlhB -
D781_RS13205 2900456..2900896 - 441 WP_015672838.1 type II toxin-antitoxin system VapC family toxin Toxin
D781_RS13210 2900893..2901129 - 237 WP_015672839.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D781_RS13215 2901260..2901904 - 645 WP_015672840.1 protein phosphatase CheZ -
D781_RS13220 2901917..2902306 - 390 WP_015672841.1 chemotaxis response regulator CheY -
D781_RS13225 2902404..2903453 - 1050 WP_015672842.1 chemotaxis response regulator protein-glutamate methylesterase -
D781_RS13230 2903453..2904313 - 861 WP_015672843.1 protein-glutamate O-methyltransferase CheR -
D781_RS13235 2904342..2905967 - 1626 WP_158497485.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16276.71 Da        Isoelectric Point: 9.8304

>T28718 WP_015672838.1 NC_020064:c2900896-2900456 [Serratia sp. FGI94]
MITHMLDTNIVIYVIKRRPREVLAVFNQHAGKMAISAVTYGELVHGVEKSARQVENLRVVEDFVSRLDVLPYTDKAAAHY
GNIRADLERKGTPIGVNDLHIAGHARSEGLVLVSNNLREFARIDGLRLENWLSSPIIPPSRPSSSK

Download         Length: 441 bp

>T28718 NC_020064:c2900896-2900456 [Serratia sp. FGI94]
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGTGAAGTACTGGCGGTATTTAA
TCAGCACGCAGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTGCACGGTGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCTCACTAT
GGCAATATTCGCGCCGATCTTGAGCGTAAAGGCACGCCGATTGGGGTTAATGACCTGCATATCGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCGCGAGTTTGCCCGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CGCCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8837.75 Da        Isoelectric Point: 4.4013

>AT28718 WP_015672839.1 NC_020064:c2901129-2900893 [Serratia sp. FGI94]
MTIGSVFTNNRSQAVRLPAEARFPDSVSKVTVRVVGKERVLAPVENTWDSFFDQESLPGDDFLNERAAQYQAERESFE

Download         Length: 237 bp

>AT28718 NC_020064:c2901129-2900893 [Serratia sp. FGI94]
ATGACTATCGGTTCCGTTTTTACCAATAATCGCTCGCAGGCGGTACGTTTGCCGGCAGAGGCGCGTTTTCCTGATTCGGT
GTCGAAGGTGACGGTGCGTGTGGTGGGTAAAGAGCGCGTTCTGGCCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACC
AGGAGAGCCTGCCAGGTGATGATTTTCTGAATGAAAGAGCCGCGCAGTATCAGGCAGAGCGGGAAAGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447QD36

Antitoxin

Source ID Structure
AlphaFold DB L0MGH9

References