287177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3357594..3358212 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EL093_RS16460 Protein ID WP_001291435.1
Coordinates 3357994..3358212 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EL093_RS16455 Protein ID WP_000344800.1
Coordinates 3357594..3357968 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS16445 3352683..3353876 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL093_RS16450 3353899..3357048 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EL093_RS16455 3357594..3357968 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EL093_RS16460 3357994..3358212 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EL093_RS16465 3358384..3358935 + 552 WP_000102564.1 maltose O-acetyltransferase -
EL093_RS16470 3359051..3359522 + 472 Protein_3195 YlaC family protein -
EL093_RS16475 3359686..3361236 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EL093_RS16480 3361278..3361631 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EL093_RS16485 3361975..3362202 - 228 WP_024183738.1 DUF2188 domain-containing protein -
EL093_RS16490 3362420..3363040 - 621 WP_001267012.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287177 WP_001291435.1 NZ_LR134227:3357994-3358212 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT287177 WP_000344800.1 NZ_LR134227:3357594-3357968 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References