Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2346402..2347040 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL093_RS11410 Protein ID WP_000813794.1
Coordinates 2346864..2347040 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL093_RS11405 Protein ID WP_001270286.1
Coordinates 2346402..2346818 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS11390 2342935..2343510 - 576 Protein_2214 ABC transporter ATP-binding protein -
EL093_RS11395 2343528..2344672 - 1145 Protein_2215 ABC transporter substrate-binding protein -
EL093_RS11400 2344917..2346323 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EL093_RS11405 2346402..2346818 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL093_RS11410 2346864..2347040 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL093_RS11415 2347262..2347492 + 231 WP_000494244.1 YncJ family protein -
EL093_RS11420 2347584..2349545 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL093_RS11425 2349618..2350154 - 537 WP_126323072.1 DNA-binding transcriptional regulator SutR -
EL093_RS11430 2350207..2351421 + 1215 WP_126323074.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287176 WP_000813794.1 NZ_LR134227:c2347040-2346864 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287176 WP_001270286.1 NZ_LR134227:c2346818-2346402 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References