287174

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233676..2234202 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL093_RS10860 Protein ID WP_000323025.1
Coordinates 2233915..2234202 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL093_RS10855 Protein ID WP_000534858.1
Coordinates 2233676..2233915 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS10805 2229476..2229667 - 192 WP_001083297.1 lysis protein YdfD -
EL093_RS10810 2229664..2229852 - 189 WP_000854559.1 cell division inhibition protein DicB -
EL093_RS10820 2230420..2230638 - 219 WP_001171942.1 hypothetical protein -
EL093_RS10825 2230798..2230953 - 156 WP_000379575.1 DUF1391 family protein -
EL093_RS10830 2231120..2231527 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
EL093_RS10835 2231611..2231703 + 93 Protein_2101 dicB transcriptional regulator DicC -
EL093_RS22285 2231697..2231906 + 210 Protein_2102 integrase core domain-containing protein -
EL093_RS22290 2232225..2232374 + 150 WP_011443592.1 hypothetical protein -
EL093_RS10845 2232811..2233143 - 333 WP_001301033.1 protein FlxA -
EL093_RS10850 2233346..2233651 - 306 WP_001326990.1 hypothetical protein -
EL093_RS10855 2233676..2233915 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL093_RS10860 2233915..2234202 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL093_RS10865 2234274..2234429 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL093_RS10870 2234712..2235362 + 651 Protein_2109 antitermination protein -
EL093_RS10875 2235640..2235729 - 90 WP_120795389.1 hypothetical protein -
EL093_RS10880 2235784..2235996 - 213 WP_000087756.1 cold shock-like protein CspF -
EL093_RS10885 2236297..2236512 + 216 WP_000066484.1 cold shock-like protein CspB -
EL093_RS22425 2236876..2237046 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL093_RS10890 2237266..2237397 + 132 Protein_2114 holin -
EL093_RS10895 2237390..2238025 - 636 Protein_2115 phage portal protein -
EL093_RS10900 2238022..2238228 - 207 WP_000198149.1 gpW family protein -
EL093_RS10905 2238225..2238668 - 444 Protein_2117 phage terminase large subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2221238..2250006 28768
- inside Prophage - - 2221238..2260567 39329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287174 WP_000323025.1 NZ_LR134227:2233915-2234202 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287174 WP_000534858.1 NZ_LR134227:2233676-2233915 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References