Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2233676..2234202 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL093_RS10860 Protein ID WP_000323025.1
Coordinates 2233915..2234202 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL093_RS10855 Protein ID WP_000534858.1
Coordinates 2233676..2233915 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS10805 2229476..2229667 - 192 WP_001083297.1 lysis protein YdfD -
EL093_RS10810 2229664..2229852 - 189 WP_000854559.1 cell division inhibition protein DicB -
EL093_RS10820 2230420..2230638 - 219 WP_001171942.1 hypothetical protein -
EL093_RS10825 2230798..2230953 - 156 WP_000379575.1 DUF1391 family protein -
EL093_RS10830 2231120..2231527 - 408 WP_000448564.1 DNA-binding transcriptional dual regulator DicA -
EL093_RS10835 2231611..2231703 + 93 Protein_2101 dicB transcriptional regulator DicC -
EL093_RS22285 2231697..2231906 + 210 Protein_2102 integrase core domain-containing protein -
EL093_RS22290 2232225..2232374 + 150 WP_011443592.1 hypothetical protein -
EL093_RS10845 2232811..2233143 - 333 WP_001301033.1 protein FlxA -
EL093_RS10850 2233346..2233651 - 306 WP_001326990.1 hypothetical protein -
EL093_RS10855 2233676..2233915 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL093_RS10860 2233915..2234202 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL093_RS10865 2234274..2234429 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL093_RS10870 2234712..2235362 + 651 Protein_2109 antitermination protein -
EL093_RS10875 2235640..2235729 - 90 WP_120795389.1 hypothetical protein -
EL093_RS10880 2235784..2235996 - 213 WP_000087756.1 cold shock-like protein CspF -
EL093_RS10885 2236297..2236512 + 216 WP_000066484.1 cold shock-like protein CspB -
EL093_RS22425 2236876..2237046 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL093_RS10890 2237266..2237397 + 132 Protein_2114 holin -
EL093_RS10895 2237390..2238025 - 636 Protein_2115 phage portal protein -
EL093_RS10900 2238022..2238228 - 207 WP_000198149.1 gpW family protein -
EL093_RS10905 2238225..2238668 - 444 Protein_2117 phage terminase large subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2221238..2250006 28768
- inside Prophage - - 2221238..2260567 39329


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287174 WP_000323025.1 NZ_LR134227:2233915-2234202 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287174 WP_000534858.1 NZ_LR134227:2233676-2233915 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References