Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 682888..683723 Replicon chromosome
Accession NZ_LR134227
Organism Escherichia coli strain NCTC9102

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag EL093_RS03325 Protein ID WP_126322993.1
Coordinates 683346..683723 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL093_RS03320 Protein ID WP_126323184.1
Coordinates 682888..683256 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL093_RS03290 678397..679719 + 1323 Protein_645 autotransporter adhesin family protein -
EL093_RS03295 680188..680957 + 770 Protein_646 autotransporter adhesin family protein -
EL093_RS03300 680956..681450 + 495 Protein_647 DUF932 domain-containing protein -
EL093_RS03305 681542..682027 + 486 WP_126322989.1 antirestriction protein -
EL093_RS03310 682043..682519 + 477 WP_126322991.1 RadC family protein -
EL093_RS03315 682588..682809 + 222 WP_089570377.1 DUF987 domain-containing protein -
EL093_RS03320 682888..683256 + 369 WP_126323184.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL093_RS03325 683346..683723 + 378 WP_126322993.1 TA system toxin CbtA family protein Toxin
EL093_RS03330 683720..684208 + 489 WP_089616157.1 hypothetical protein -
EL093_RS03335 684220..684417 + 198 WP_126322995.1 DUF957 domain-containing protein -
EL093_RS03340 684514..685359 + 846 WP_126323185.1 DUF4942 domain-containing protein -
EL093_RS03350 685659..686165 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
EL093_RS03355 686244..688086 - 1843 Protein_657 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 656370..706623 50253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14306.41 Da        Isoelectric Point: 9.5914

>T287165 WP_126322993.1 NZ_LR134227:683346-683723 [Escherichia coli]
MKTLSDTHVRKASRCPCPVTIWQTLLTRLLDQHYGLTLNDTPFADKRVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKYQEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.36 Da        Isoelectric Point: 6.6252

>AT287165 WP_126323184.1 NZ_LR134227:682888-683256 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References