Detailed information of TA system TA287165

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 682888..683723
• Replicon: chromosome
• Accession: NZ_LR134227
• Organism: Escherichia coli strain NCTC9102

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: EL093_RS03325
• Protein ID: WP_126322993.1
• Coordinates: 683346..683723 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: EL093_RS03320
• Protein ID: WP_126323184.1
• Coordinates: 682888..683256 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL093_RS03290	678397..679719	+	1323	Protein_645	autotransporter adhesin family protein	-
EL093_RS03295	680188..680957	+	770	Protein_646	autotransporter adhesin family protein	-
EL093_RS03300	680956..681450	+	495	Protein_647	DUF932 domain-containing protein	-
EL093_RS03305	681542..682027	+	486	WP_126322989.1	antirestriction protein	-
EL093_RS03310	682043..682519	+	477	WP_126322991.1	RadC family protein	-
EL093_RS03315	682588..682809	+	222	WP_089570377.1	DUF987 domain-containing protein	-
EL093_RS03320	682888..683256	+	369	WP_126323184.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EL093_RS03325	683346..683723	+	378	WP_126322993.1	TA system toxin CbtA family protein	Toxin
EL093_RS03330	683720..684208	+	489	WP_089616157.1	hypothetical protein	-
EL093_RS03335	684220..684417	+	198	WP_126322995.1	DUF957 domain-containing protein	-
EL093_RS03340	684514..685359	+	846	WP_126323185.1	DUF4942 domain-containing protein	-
EL093_RS03350	685659..686165	+	507	WP_000228937.1	G/U mismatch-specific DNA glycosylase	-
EL093_RS03355	686244..688086	-	1843	Protein_657	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	rfaE	656370..706623	50253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14306.41 Da
• Isoelectric Point: 9.5914

>T287165 WP_126322993.1 NZ_LR134227:683346-683723 [Escherichia coli]
MKTLSDTHVRKASRCPCPVTIWQTLLTRLLDQHYGLTLNDTPFADKRVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKYQEAKR

Nucleotide

• Length: 378 bp

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13614.36 Da
• Isoelectric Point: 6.6252

>AT287165 WP_126323184.1 NZ_LR134227:682888-683256 [Escherichia coli]
VSDTLPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp