287150

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1307565..1308190 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag EL094_RS06440 Protein ID WP_000911329.1
Coordinates 1307792..1308190 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag EL094_RS06435 Protein ID WP_000450524.1
Coordinates 1307565..1307792 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS06410 1303367..1303837 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
EL094_RS06415 1303837..1304409 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
EL094_RS06420 1304555..1305433 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
EL094_RS06425 1305450..1306484 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
EL094_RS06430 1306697..1307410 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
EL094_RS06435 1307565..1307792 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
EL094_RS06440 1307792..1308190 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
EL094_RS06445 1308337..1309200 + 864 WP_001267498.1 neutral zinc metallopeptidase -
EL094_RS06450 1309215..1311230 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
EL094_RS06455 1311304..1312002 + 699 WP_000679823.1 esterase -
EL094_RS06460 1312083..1312283 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T287150 WP_000911329.1 NZ_LR134226:1307792-1308190 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT287150 WP_000450524.1 NZ_LR134226:1307565-1307792 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References