Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 263003..263634 Replicon chromosome
Accession NZ_LR134226
Organism Escherichia coli strain NCTC9088

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag EL094_RS01225 Protein ID WP_001259385.1
Coordinates 263003..263278 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag EL094_RS01230 Protein ID WP_000593555.1
Coordinates 263275..263634 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL094_RS01210 258021..259088 + 1068 WP_021565451.1 HlyD family secretion protein -
EL094_RS01215 259085..261820 + 2736 WP_021565452.1 ribosome-associated ATPase/putative transporter RbbA -
EL094_RS01220 261820..262944 + 1125 WP_021565453.1 ABC transporter permease -
EL094_RS01225 263003..263278 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
EL094_RS01230 263275..263634 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL094_RS01235 263684..264544 - 861 WP_001131788.1 class II aldolase -
EL094_RS01240 264576..264845 - 270 WP_000933061.1 HPr family phosphocarrier protein -
EL094_RS01245 264835..266343 - 1509 WP_021565454.1 xylulose kinase -
EL094_RS01250 266336..267694 - 1359 WP_021565455.1 PTS galactitol transporter subunit IIC -
EL094_RS01255 267771..268052 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
EL094_RS01260 268049..268522 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T287146 WP_001259385.1 NZ_LR134226:263003-263278 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT287146 WP_000593555.1 NZ_LR134226:263275-263634 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References