Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4638730..4639255 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag EL113_RS22785 Protein ID WP_016240353.1
Coordinates 4638730..4639035 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A8H9ZZC6
Locus tag EL113_RS22790 Protein ID WP_016240352.1
Coordinates 4639037..4639255 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS22760 4634140..4635429 - 1290 WP_003026002.1 arsenite efflux transporter membrane subunit ArsB -
EL113_RS22765 4635478..4637229 - 1752 WP_001556710.1 arsenite efflux transporter ATPase subunit ArsA -
EL113_RS22770 4637247..4637609 - 363 WP_000783215.1 arsenite efflux transporter metallochaperone ArsD -
EL113_RS22775 4637657..4638010 - 354 WP_001114073.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
EL113_RS22780 4638285..4638560 - 276 Protein_4380 hypothetical protein -
EL113_RS22785 4638730..4639035 - 306 WP_016240353.1 type II toxin-antitoxin system toxin CcdB Toxin
EL113_RS22790 4639037..4639255 - 219 WP_016240352.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
EL113_RS22805 4639855..4640085 + 231 WP_001261283.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
EL113_RS22810 4640082..4640498 + 417 WP_032192044.1 type II toxin-antitoxin system VapC family toxin -
EL113_RS22815 4640534..4640785 + 252 WP_105966327.1 hypothetical protein -
EL113_RS22820 4640866..4641966 - 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11518.20 Da        Isoelectric Point: 5.6752

>T287143 WP_016240353.1 NZ_LR134222:c4639035-4638730 [Escherichia coli]
MQFKVYAYKRESCYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8321.25 Da        Isoelectric Point: 4.5358

>AT287143 WP_016240352.1 NZ_LR134222:c4639255-4639037 [Escherichia coli]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References