Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4444990..4446034 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag EL113_RS21885 Protein ID WP_000019186.1
Coordinates 4444990..4445538 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag EL113_RS21890 Protein ID WP_000287252.1
Coordinates 4445561..4446034 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS21840 4440202..4440753 - 552 WP_000515860.1 hypothetical protein -
EL113_RS21845 4440797..4440997 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
EL113_RS21850 4441088..4441762 + 675 WP_000859462.1 LexA family transcriptional repressor -
EL113_RS21865 4442429..4442791 + 363 WP_000135682.1 hypothetical protein -
EL113_RS21870 4442857..4443681 + 825 WP_001753751.1 DUF2303 family protein -
EL113_RS21875 4443898..4444650 + 753 WP_001701368.1 hypothetical protein -
EL113_RS21880 4444687..4444956 + 270 WP_001093912.1 pyocin activator PrtN family protein -
EL113_RS21885 4444990..4445538 - 549 WP_000019186.1 hypothetical protein Toxin
EL113_RS21890 4445561..4446034 - 474 WP_000287252.1 SocA family protein Antitoxin
EL113_RS21895 4446321..4446443 - 123 WP_001300034.1 hypothetical protein -
EL113_RS21900 4446807..4447797 - 991 Protein_4223 DUF2713 domain-containing protein -
EL113_RS21910 4448115..4448630 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
EL113_RS21915 4448672..4448881 - 210 WP_001030593.1 CsbD family protein -
EL113_RS21920 4448997..4450322 - 1326 WP_001298861.1 MATE family efflux transporter DinF -
EL113_RS21925 4450395..4451003 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4399408..4451003 51595


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T287141 WP_000019186.1 NZ_LR134222:c4445538-4444990 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT287141 WP_000287252.1 NZ_LR134222:c4446034-4445561 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References