Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2460160..2460798 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EL113_RS12140 Protein ID WP_000813794.1
Coordinates 2460622..2460798 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL113_RS12135 Protein ID WP_001270286.1
Coordinates 2460160..2460576 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS12115 2455312..2456253 - 942 WP_001251319.1 ABC transporter permease -
EL113_RS12120 2456254..2457267 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
EL113_RS12125 2457285..2458430 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
EL113_RS12130 2458675..2460081 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
EL113_RS12135 2460160..2460576 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL113_RS12140 2460622..2460798 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL113_RS12145 2461020..2461250 + 231 WP_000494244.1 YncJ family protein -
EL113_RS12150 2461342..2463303 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL113_RS12155 2463376..2463912 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
EL113_RS12160 2463965..2465179 + 1215 WP_001349372.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2465219..2466484 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T287133 WP_000813794.1 NZ_LR134222:c2460798-2460622 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT287133 WP_001270286.1 NZ_LR134222:c2460576-2460160 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References