Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2283611..2284137 Replicon chromosome
Accession NZ_LR134222
Organism Escherichia coli strain NCTC11129

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EL113_RS11290 Protein ID WP_000323025.1
Coordinates 2283850..2284137 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EL113_RS11285 Protein ID WP_000534858.1
Coordinates 2283611..2283850 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL113_RS11255 2278945..2279301 + 357 WP_001374839.1 class I SAM-dependent methyltransferase -
EL113_RS24915 2279912..2280199 + 288 Protein_2161 hypothetical protein -
EL113_RS11270 2280968..2282309 + 1342 Protein_2162 ISNCY family transposase -
EL113_RS11275 2282746..2283078 - 333 WP_001317460.1 FlxA-like family protein -
EL113_RS11280 2283281..2283586 - 306 WP_001326990.1 hypothetical protein -
EL113_RS11285 2283611..2283850 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EL113_RS11290 2283850..2284137 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EL113_RS11295 2284209..2284364 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EL113_RS11300 2284581..2284832 + 252 WP_000980994.1 hypothetical protein -
EL113_RS11305 2284899..2285177 + 279 WP_012304870.1 hypothetical protein -
EL113_RS11310 2285179..2286228 + 1050 WP_001265198.1 DUF968 domain-containing protein -
EL113_RS11315 2286242..2286994 + 753 WP_001047135.1 antitermination protein -
EL113_RS11320 2287272..2287361 - 90 WP_120795389.1 hypothetical protein -
EL113_RS11325 2287416..2287628 - 213 WP_000087756.1 cold shock-like protein CspF -
EL113_RS11330 2287929..2288144 + 216 WP_000066484.1 cold shock-like protein CspB -
EL113_RS25045 2288508..2288678 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
EL113_RS11335 2288898..2289113 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2258717..2319521 60804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T287131 WP_000323025.1 NZ_LR134222:2283850-2284137 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT287131 WP_000534858.1 NZ_LR134222:2283611-2283850 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References