Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1147037..1147704 Replicon chromosome
Accession NZ_LR134220
Organism Escherichia coli strain NCTC11121

Toxin (Protein)


Gene name ypjF Uniprot ID A0A156PNF2
Locus tag EL088_RS05560 Protein ID WP_001618791.1
Coordinates 1147037..1147366 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A156PNH9
Locus tag EL088_RS05565 Protein ID WP_001618790.1
Coordinates 1147387..1147704 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL088_RS05555 1142093..1146673 + 4581 WP_111724795.1 adhesin-like autotransporter YpjA/EhaD -
EL088_RS05560 1147037..1147366 - 330 WP_001618791.1 TA system toxin CbtA family protein Toxin
EL088_RS05565 1147387..1147704 - 318 WP_001618790.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL088_RS05570 1147723..1147944 - 222 WP_044864853.1 DUF987 domain-containing protein -
EL088_RS05575 1147953..1148429 - 477 WP_000811693.1 RadC family protein -
EL088_RS05580 1148445..1148903 - 459 WP_000211838.1 antirestriction protein -
EL088_RS05585 1149001..1149240 - 240 WP_000194654.1 DUF905 domain-containing protein -
EL088_RS05590 1149317..1149784 - 468 WP_001547765.1 hypothetical protein -
EL088_RS05595 1149807..1150250 - 444 WP_032199444.1 hypothetical protein -
EL088_RS05600 1150250..1150486 - 237 WP_001144031.1 hypothetical protein -
EL088_RS05605 1150527..1151228 - 702 WP_111724571.1 WYL domain-containing protein -
EL088_RS05610 1151445..1152266 - 822 WP_111724572.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1138092..1178925 40833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12509.43 Da        Isoelectric Point: 7.2767

>T287110 WP_001618791.1 NZ_LR134220:c1147366-1147037 [Escherichia coli]
MNTLPATTQRAAKPCLSPVAVWKMLLTHLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADTVNFLVEKYELVRIDRKGF
SWQEQTPYISVVDILRARRSTDLLKTNVK

Download         Length: 330 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11905.54 Da        Isoelectric Point: 7.3234

>AT287110 WP_001618790.1 NZ_LR134220:c1147704-1147387 [Escherichia coli]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGEVSPQHAHCVILYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A156PNF2

Antitoxin

Source ID Structure
AlphaFold DB A0A156PNH9

References