Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3985224..3986056 Replicon chromosome
Accession NZ_LR134216
Organism Escherichia coli strain NCTC10973

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag EL103_RS19325 Protein ID WP_000854753.1
Coordinates 3985224..3985598 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag EL103_RS19330 Protein ID WP_021542768.1
Coordinates 3985688..3986056 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL103_RS19280 3980439..3981545 + 1107 WP_001353974.1 N-acetylneuraminate epimerase -
EL103_RS19285 3981610..3982590 + 981 WP_021542769.1 transposase -
EL103_RS19290 3982598..3983248 - 651 WP_001037966.1 HNH endonuclease -
EL103_RS22605 3984293..3984445 - 153 WP_001280445.1 hypothetical protein -
EL103_RS19315 3984530..3984727 - 198 WP_000839281.1 DUF957 domain-containing protein -
EL103_RS19320 3984739..3985227 - 489 WP_000777547.1 hypothetical protein -
EL103_RS19325 3985224..3985598 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
EL103_RS19330 3985688..3986056 - 369 WP_021542768.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL103_RS19335 3986219..3986440 - 222 WP_000692345.1 DUF987 domain-containing protein -
EL103_RS19340 3986503..3986979 - 477 WP_001186774.1 RadC family protein -
EL103_RS19345 3986995..3987480 - 486 WP_000849588.1 antirestriction protein -
EL103_RS19350 3987535..3988353 - 819 WP_001234620.1 DUF945 domain-containing protein -
EL103_RS19360 3988453..3988686 - 234 WP_001119729.1 DUF905 family protein -
EL103_RS19365 3988765..3989220 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T287103 WP_000854753.1 NZ_LR134216:c3985598-3985224 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13573.33 Da        Isoelectric Point: 6.4789

>AT287103 WP_021542768.1 NZ_LR134216:c3986056-3985688 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWRLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure

References