Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1106279..1106910 Replicon chromosome
Accession NC_020064
Organism Serratia marcescens FGI94

Toxin (Protein)


Gene name Hha Uniprot ID L0MF14
Locus tag D781_RS04975 Protein ID WP_015671220.1
Coordinates 1106279..1106482 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID L0MF73
Locus tag D781_RS04980 Protein ID WP_015671221.1
Coordinates 1106542..1106910 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D781_RS04955 1101471..1101893 + 423 WP_015671216.1 hypothetical protein -
D781_RS04960 1101928..1103271 - 1344 WP_015671217.1 NCS2 family permease -
D781_RS04965 1103341..1105128 - 1788 WP_015671218.1 adenine deaminase -
D781_RS04970 1105266..1106198 + 933 WP_015671219.1 LysR family transcriptional regulator -
D781_RS04975 1106279..1106482 - 204 WP_015671220.1 hemolysin expression modulator Hha Toxin
D781_RS04980 1106542..1106910 - 369 WP_015671221.1 Hha toxicity modulator TomB Antitoxin
D781_RS22525 1107267..1107620 - 354 WP_015671222.1 hypothetical protein -
D781_RS23830 1107782..1107931 + 150 WP_015671223.1 hypothetical protein -
D781_RS04985 1107928..1108632 + 705 WP_015671224.1 ABC transporter ATP-binding protein -
D781_RS04990 1108629..1109495 + 867 WP_015671225.1 metal ABC transporter permease -
D781_RS04995 1109511..1110386 + 876 WP_015671226.1 metal ABC transporter substrate-binding protein -
D781_RS22530 1110484..1110624 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
D781_RS05000 1110634..1110888 - 255 WP_015671227.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8049.33 Da        Isoelectric Point: 7.9816

>T28709 WP_015671220.1 NC_020064:c1106482-1106279 [Serratia sp. FGI94]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T28709 NC_020064:c1106482-1106279 [Serratia sp. FGI94]
ATGACAAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
GTACGCGCTCTCTGACGATGAGCTCGAGCTGTTTTACTCCGCAGCCGACCATCGTCTGGCTGAACTCACCATGAATAAGC
TGTATGACAAAATCCCGACGTCTGTTTGGAAATATGTAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14294.06 Da        Isoelectric Point: 4.6346

>AT28709 WP_015671221.1 NC_020064:c1106910-1106542 [Serratia sp. FGI94]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKRRLFGMFSGEVCCTKMKT

Download         Length: 369 bp

>AT28709 NC_020064:c1106910-1106542 [Serratia sp. FGI94]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAAAATCTGTACGATGAAGGCATAGC
GACGTTGGGCGACAGCCACCACGGCTGGGTTAACGATCCGACATCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGCTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTACCTC
GACGATACCTATACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGTCGTTGGCAAAAAACTAAACGGCGACT
ATTCGGAATGTTCTCAGGGGAGGTTTGCTGTACGAAAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857EAE6

Antitoxin

Source ID Structure
AlphaFold DB L0MF73

References