Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2183153..2183704 Replicon chromosome
Accession NZ_LR134215
Organism Shimwellia blattae strain NCTC12127

Toxin (Protein)


Gene name ccdB Uniprot ID I2B9K3
Locus tag EL083_RS10450 Protein ID WP_002443590.1
Coordinates 2183153..2183470 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I2B9K4
Locus tag EL083_RS10455 Protein ID WP_002443589.1
Coordinates 2183474..2183704 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL083_RS10415 2178342..2178554 - 213 WP_002443597.1 hypothetical protein -
EL083_RS10420 2178655..2179269 - 615 WP_002443596.1 membrane integrity-associated transporter subunit PqiC -
EL083_RS10425 2179266..2180174 - 909 WP_002443595.1 MCE family protein -
EL083_RS10430 2180176..2180949 - 774 WP_002443594.1 ATP-binding cassette domain-containing protein -
EL083_RS10435 2180952..2182079 - 1128 WP_002443593.1 ABC transporter permease -
EL083_RS10440 2182290..2182580 + 291 WP_002443592.1 hypothetical protein -
EL083_RS10445 2182623..2182868 - 246 WP_002443591.1 YfdY family protein -
EL083_RS10450 2183153..2183470 - 318 WP_002443590.1 CcdB family protein Toxin
EL083_RS10455 2183474..2183704 - 231 WP_002443589.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL083_RS10460 2183888..2184526 - 639 WP_002443588.1 leucine efflux protein LeuE -
EL083_RS10465 2184698..2185228 - 531 WP_002443587.1 cytochrome b561 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-104)

Antitoxin

Post-segregation antitoxin CcdA

(7-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11725.67 Da        Isoelectric Point: 5.0491

>T287084 WP_002443590.1 NZ_LR134215:c2183470-2183153 [Shimwellia blattae]
MQFTIYRNPGRSSLYPLLIDVTSDIIGALNTRIVIPLLPVERYPNPEVRPVRLNPVLELIDGKQYALMTHELASIPLKAL
GAEFCDGSEYRQTVKGALDFILDGI

Download         Length: 318 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8613.57 Da        Isoelectric Point: 6.8798

>AT287084 WP_002443589.1 NZ_LR134215:c2183704-2183474 [Shimwellia blattae]
MKQRTTQSVTVTLERDLIAAARAAGVNMSQTLAAALDAELKKHASTRWKEENREGLEALNRFHDEHGHFSDDYRAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2B9K3

Antitoxin

Source ID Structure
AlphaFold DB I2B9K4

References