Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1598883..1599473 Replicon chromosome
Accession NZ_LR134215
Organism Shimwellia blattae strain NCTC12127

Toxin (Protein)


Gene name pemK Uniprot ID I2B7X3
Locus tag EL083_RS07525 Protein ID WP_002440075.1
Coordinates 1599141..1599473 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID I2B7X2
Locus tag EL083_RS07520 Protein ID WP_002440074.1
Coordinates 1598883..1599140 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL083_RS07495 1594068..1595516 - 1449 WP_002440068.1 AMP nucleosidase -
EL083_RS07505 1596651..1597568 + 918 WP_002440070.1 nitrogen assimilation transcriptional regulator NAC -
EL083_RS07510 1597674..1598624 + 951 WP_002440072.1 HTH-type transcriptional regulator Cbl -
EL083_RS07520 1598883..1599140 + 258 WP_002440074.1 hypothetical protein Antitoxin
EL083_RS07525 1599141..1599473 + 333 WP_002440075.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL083_RS07535 1599715..1600500 - 786 WP_002440077.1 DgsA anti-repressor MtfA -
EL083_RS07545 1600857..1601495 + 639 WP_002440078.1 GrpB family protein -
EL083_RS07550 1601641..1601904 + 264 WP_034920043.1 hypothetical protein -
EL083_RS07555 1602077..1603513 + 1437 WP_174270544.1 DNA cytosine methyltransferase -
EL083_RS07560 1603497..1603970 + 474 WP_002440083.1 DNA mismatch endonuclease Vsr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-85)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11760.52 Da        Isoelectric Point: 10.2965

>T287077 WP_002440075.1 NZ_LR134215:1599141-1599473 [Shimwellia blattae]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSKASFNTFTRLPVVVPVTSGGNFARTAGFAVSLDGAGTKTTGVIRCDQPRTI
DMAARNGKRLERLPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9412.93 Da        Isoelectric Point: 4.4750

>AT287077 WP_002440074.1 NZ_LR134215:1598883-1599140 [Shimwellia blattae]
MYTTRLKKVGGSVMLAVPPVVLKTLSLSVDSEVGMTIENGCLIIEPQKRPRYSLEELLAQCEPHAEMSEEDREWIDAPAA
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2B7X3

Antitoxin

Source ID Structure
AlphaFold DB I2B7X2

References