287067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3520524..3521144 Replicon chromosome
Accession NZ_LR134214
Organism Citrobacter portucalensis strain NCTC11104

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag EL073_RS17410 Protein ID WP_002892050.1
Coordinates 3520926..3521144 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag EL073_RS17405 Protein ID WP_003021733.1
Coordinates 3520524..3520898 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL073_RS17395 3515670..3516863 + 1194 WP_126319001.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL073_RS17400 3516886..3520035 + 3150 WP_126319003.1 efflux RND transporter permease AcrB -
EL073_RS17405 3520524..3520898 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
EL073_RS17410 3520926..3521144 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
EL073_RS17415 3521326..3521877 + 552 WP_003835924.1 maltose O-acetyltransferase -
EL073_RS17420 3521994..3522464 + 471 WP_126319005.1 hypothetical protein -
EL073_RS17425 3522543..3522683 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
EL073_RS17430 3522685..3522945 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
EL073_RS17435 3523134..3524687 + 1554 WP_126319006.1 EAL domain-containing protein -
EL073_RS17440 3524739..3525092 - 354 WP_003831033.1 DUF1428 family protein -
EL073_RS17445 3525157..3525786 - 630 WP_126319008.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T287067 WP_002892050.1 NZ_LR134214:3520926-3521144 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT287067 WP_003021733.1 NZ_LR134214:3520524-3520898 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References