Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2400634..2401370 Replicon chromosome
Accession NZ_LR134214
Organism Citrobacter portucalensis strain NCTC11104

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EL073_RS11885 Protein ID WP_126318108.1
Coordinates 2400888..2401370 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EL073_RS11880 Protein ID WP_008784769.1
Coordinates 2400634..2400900 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL073_RS11860 2395899..2396528 + 630 WP_003832974.1 winged helix-turn-helix transcriptional regulator -
EL073_RS11865 2396645..2397031 - 387 WP_063941972.1 hypothetical protein -
EL073_RS11875 2398497..2400480 + 1984 Protein_2274 MBL fold metallo-hydrolase -
EL073_RS11880 2400634..2400900 + 267 WP_008784769.1 DUF1778 domain-containing protein Antitoxin
EL073_RS11885 2400888..2401370 + 483 WP_126318108.1 GNAT family N-acetyltransferase Toxin
EL073_RS23100 2401624..2401791 - 168 Protein_2277 glyceraldehyde-3-phosphate dehydrogenase -
EL073_RS11890 2401777..2402960 - 1184 Protein_2278 mechanosensitive ion channel family protein -
EL073_RS11895 2403340..2403717 + 378 WP_003832962.1 hypothetical protein -
EL073_RS11900 2403771..2404606 + 836 Protein_2280 DMT family transporter -
EL073_RS11905 2404616..2405137 - 522 WP_126319810.1 GNAT family N-acetyltransferase -
EL073_RS11910 2405248..2406006 + 759 WP_126318110.1 trans-aconitate 2-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2395497..2405137 9640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(74-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17655.49 Da        Isoelectric Point: 9.8994

>T287066 WP_126318108.1 NZ_LR134214:2400888-2401370 [Citrobacter portucalensis]
VGFVTAPEPLTHIHRLAEFVSGEIILDDWLKQKGLKNQALGAARTFVVCKTDTRQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10159.65 Da        Isoelectric Point: 4.6558

>AT287066 WP_008784769.1 NZ_LR134214:2400634-2400900 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References