Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 437183..437826 Replicon chromosome
Accession NC_020059
Organism Rhizobium tropici CIAT 899

Toxin (Protein)


Gene name vapC Uniprot ID A0A5F1SBB7
Locus tag RTCIAT899_RS02135 Protein ID WP_015338578.1
Coordinates 437183..437587 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5F1SD67
Locus tag RTCIAT899_RS02140 Protein ID WP_015338579.1
Coordinates 437584..437826 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RTCIAT899_RS02100 432262..433218 + 957 WP_015338571.1 LysR family transcriptional regulator -
RTCIAT899_RS02105 433219..434094 - 876 WP_015338572.1 LysR family transcriptional regulator -
RTCIAT899_RS02110 434193..435476 + 1284 WP_041677179.1 MFS transporter -
RTCIAT899_RS02115 435492..435878 + 387 WP_015338574.1 VOC family protein -
RTCIAT899_RS02120 435969..436310 + 342 WP_015338575.1 metalloregulator ArsR/SmtB family transcription factor -
RTCIAT899_RS02125 436294..436782 + 489 WP_015338576.1 SRPBCC domain-containing protein -
RTCIAT899_RS02130 436782..437186 + 405 WP_041677181.1 GFA family protein -
RTCIAT899_RS02135 437183..437587 - 405 WP_015338578.1 type II toxin-antitoxin system VapC family toxin Toxin
RTCIAT899_RS02140 437584..437826 - 243 WP_015338579.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RTCIAT899_RS02145 437892..438566 - 675 WP_015338580.1 hypothetical protein -
RTCIAT899_RS02150 438638..440299 - 1662 WP_015338581.1 urocanate hydratase -
RTCIAT899_RS02155 440689..441789 - 1101 WP_015338582.1 DUF917 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14958.13 Da        Isoelectric Point: 6.3333

>T28706 WP_015338578.1 NC_020059:c437587-437183 [Rhizobium tropici CIAT 899]
VKYLLDSNAVIALMKGHPGFVSELRRHKPHDFAIPAIVVHELFYGAYKGQRVVDNLARVDALQFETLDFDKEDARVAGEI
RASLASLGTPIGTYDVLIAGQAVARDLILITHNVREFERVAKLRFEDWESLPSG

Download         Length: 405 bp

>T28706 NC_020059:c437587-437183 [Rhizobium tropici CIAT 899]
GTGAAGTATCTGCTCGACAGCAATGCCGTTATCGCCCTGATGAAAGGACACCCCGGCTTCGTCAGCGAGCTTCGCAGACA
TAAGCCCCACGATTTTGCCATTCCGGCCATCGTCGTACACGAGTTGTTTTATGGCGCTTACAAGGGCCAGCGCGTTGTCG
ACAATCTGGCACGTGTGGATGCCTTGCAGTTCGAGACGCTGGATTTCGATAAGGAAGATGCCCGTGTAGCCGGTGAAATT
CGCGCAAGCCTTGCTTCCCTTGGCACACCGATCGGTACCTATGACGTTCTGATCGCGGGCCAAGCGGTCGCCCGCGATCT
GATCCTGATAACGCACAATGTCAGAGAGTTTGAACGCGTTGCCAAGCTACGTTTCGAAGACTGGGAGTCCTTGCCGAGCG
GCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9297.43 Da        Isoelectric Point: 4.2403

>AT28706 WP_015338579.1 NC_020059:c437826-437584 [Rhizobium tropici CIAT 899]
MDTAKIFWSGRSQAVRLPKEFRLDGEEVRIRRQGKAIILEPIAEDWDWLETVTGPVDPDFEEAATEQPAEQQRPELDIFK

Download         Length: 243 bp

>AT28706 NC_020059:c437826-437584 [Rhizobium tropici CIAT 899]
ATGGACACCGCAAAGATCTTCTGGTCCGGCCGCTCGCAGGCCGTACGCTTGCCGAAGGAATTCCGCCTCGATGGCGAGGA
AGTACGCATCCGCCGGCAGGGAAAAGCAATCATTCTGGAGCCGATCGCCGAAGATTGGGATTGGCTGGAGACTGTTACGG
GGCCGGTCGACCCCGATTTTGAAGAGGCGGCGACGGAACAGCCTGCCGAGCAGCAACGCCCCGAGTTGGATATCTTCAAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1SBB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1SD67

References