Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2646808..2648396 Replicon chromosome
Accession NZ_LR134213
Organism Klebsiella pneumoniae strain NCTC418

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag EL132_RS14800 Protein ID WP_002904792.1
Coordinates 2646808..2648130 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL132_RS14805 Protein ID WP_004176198.1
Coordinates 2648130..2648396 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL132_RS14780 2641864..2644365 + 2502 WP_004224759.1 fimbrial biogenesis outer membrane usher protein -
EL132_RS14785 2644353..2645357 + 1005 WP_004224758.1 type 1 fimbrial protein -
EL132_RS14795 2645499..2646791 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
EL132_RS14800 2646808..2648130 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
EL132_RS14805 2648130..2648396 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL132_RS14810 2648783..2649109 - 327 WP_004224757.1 hydroxyisourate hydrolase -
EL132_RS14815 2649106..2649606 - 501 WP_004224756.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EL132_RS14820 2649584..2650963 - 1380 WP_014599164.1 purine permease -
EL132_RS14825 2651309..2652463 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
EL132_RS14830 2652444..2653367 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T287055 WP_002904792.1 NZ_LR134213:c2648130-2646808 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT287055 WP_004176198.1 NZ_LR134213:c2648396-2648130 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure

References