Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 201203..201942 Replicon chromosome
Accession NZ_LR134213
Organism Klebsiella pneumoniae strain NCTC418

Toxin (Protein)


Gene name tacT Uniprot ID A0A4U9WP91
Locus tag EL132_RS02590 Protein ID WP_004901283.1
Coordinates 201457..201942 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag EL132_RS02585 Protein ID WP_003026799.1
Coordinates 201203..201469 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL132_RS02570 196707..198776 + 2070 WP_004901297.1 glycine--tRNA ligase subunit beta -
EL132_RS02575 199072..200441 + 1370 WP_087661561.1 IS3 family transposase -
EL132_RS02580 200642..201070 + 429 WP_004901287.1 GFA family protein -
EL132_RS02585 201203..201469 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
EL132_RS02590 201457..201942 + 486 WP_004901283.1 GNAT family N-acetyltransferase Toxin
EL132_RS02595 202267..203313 - 1047 WP_004173931.1 IS481-like element ISKpn28 family transposase -
EL132_RS02600 203387..203539 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
EL132_RS02605 203841..205460 + 1620 WP_004901278.1 ATP-binding cassette domain-containing protein -
EL132_RS02610 205559..205771 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
EL132_RS02615 206023..206313 - 291 WP_002921931.1 HTH-type transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 199716..203313 3597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.32 Da        Isoelectric Point: 10.1788

>T287049 WP_004901283.1 NZ_LR134213:201457-201942 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLNQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT287049 WP_003026799.1 NZ_LR134213:201203-201469 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9WP91

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References