Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 57664..58400 Replicon plasmid 2
Accession NZ_LR134211
Organism Klebsiella pneumoniae strain NCTC418

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag EL132_RS00545 Protein ID WP_004098919.1
Coordinates 57664..58146 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag EL132_RS00550 Protein ID WP_004213599.1
Coordinates 58134..58400 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL132_RS00525 53018..54364 + 1347 WP_011154555.1 dihydroorotase -
EL132_RS00530 54428..55450 + 1023 WP_004214536.1 porphobilinogen synthase -
EL132_RS00535 55625..56020 + 396 Protein_61 DDE-type integrase/transposase/recombinase -
EL132_RS00540 56016..57243 - 1228 Protein_62 IS3 family transposase -
EL132_RS00545 57664..58146 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
EL132_RS00550 58134..58400 - 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
EL132_RS00555 58574..58888 - 315 Protein_65 DNA-binding protein -
EL132_RS00560 58930..61899 - 2970 WP_004213592.1 Tn3 family transposase -
EL132_RS00565 61902..62459 - 558 WP_004213590.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iucA / iucB / iucC / iucD / iutA / rmpA2 / iroB / iroC / iroD / iroN / rmpA 1..205331 205331
- inside IScluster/Tn - - 56016..62459 6443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T287046 WP_004098919.1 NZ_LR134211:c58146-57664 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT287046 WP_004213599.1 NZ_LR134211:c58400-58134 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References