Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 12498..13249 Replicon plasmid 2
Accession NZ_LR134211
Organism Klebsiella pneumoniae strain NCTC418

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag EL132_RS00290 Protein ID WP_004902249.1
Coordinates 12767..13249 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag EL132_RS00285 Protein ID WP_004902250.1
Coordinates 12498..12776 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL132_RS00250 7526..7816 + 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -
EL132_RS00255 7834..9099 + 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
EL132_RS00260 9080..10750 + 1671 WP_004902261.1 AMP-binding protein -
EL132_RS28115 10988..11257 + 270 WP_071591895.1 hypothetical protein -
EL132_RS00275 11718..12059 + 342 WP_004902257.1 hypothetical protein -
EL132_RS00280 12167..12379 + 213 WP_004902255.1 hypothetical protein -
EL132_RS00285 12498..12776 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
EL132_RS00290 12767..13249 + 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
EL132_RS00305 14284..14823 + 540 WP_004902239.1 hypothetical protein -
EL132_RS00310 14928..15320 + 393 WP_045145491.1 hypothetical protein -
EL132_RS00315 15421..16176 + 756 WP_004902235.1 DUF2971 domain-containing protein -
EL132_RS00320 16203..16850 + 648 WP_014386537.1 EcsC family protein -
EL132_RS00325 16982..17218 - 237 Protein_20 kinase -
EL132_RS00330 17275..18243 - 969 WP_004225014.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iucA / iucB / iucC / iucD / iutA / rmpA2 / iroB / iroC / iroD / iroN / rmpA 1..205331 205331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T287045 WP_004902249.1 NZ_LR134211:12767-13249 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT287045 WP_004902250.1 NZ_LR134211:12498-12776 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References