Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3868943..3870514 Replicon chromosome
Accession NZ_LR134205
Organism Proteus mirabilis strain NCTC4199

Toxin (Protein)


Gene name hipA Uniprot ID A0A411AN16
Locus tag EL062_RS17715 Protein ID WP_036895880.1
Coordinates 3868943..3870256 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag EL062_RS17720 Protein ID WP_004249771.1
Coordinates 3870257..3870514 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL062_RS17695 3864113..3864916 + 804 WP_004249775.1 energy transducer TonB -
EL062_RS17700 3864970..3866931 - 1962 WP_049208705.1 hypothetical protein -
EL062_RS17705 3866963..3867892 - 930 WP_004246518.1 metallophosphoesterase -
EL062_RS17710 3868077..3868541 - 465 WP_004246516.1 DUF1097 domain-containing protein -
EL062_RS17715 3868943..3870256 - 1314 WP_036895880.1 type II toxin-antitoxin system HipA family toxin Toxin
EL062_RS17720 3870257..3870514 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
EL062_RS17725 3870663..3872027 - 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
EL062_RS17730 3872165..3873805 - 1641 WP_004246512.1 membrane protein insertase YidC -
EL062_RS17735 3873808..3874068 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
EL062_RS17740 3874032..3874391 - 360 WP_004246510.1 ribonuclease P protein component -
EL062_RS17745 3874409..3874552 - 144 WP_004246509.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49698.84 Da        Isoelectric Point: 6.5023

>T287029 WP_036895880.1 NZ_LR134205:c3870256-3868943 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT287029 WP_004249771.1 NZ_LR134205:c3870514-3870257 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411AN16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References