Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3603322..3603971 Replicon chromosome
Accession NZ_LR134205
Organism Proteus mirabilis strain NCTC4199

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag EL062_RS16550 Protein ID WP_012368534.1
Coordinates 3603322..3603741 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag EL062_RS16555 Protein ID WP_012368535.1
Coordinates 3603738..3603971 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL062_RS16510 3598599..3599477 - 879 WP_049203255.1 23S rRNA pseudouridine(2604) synthase RluF -
EL062_RS16515 3599653..3600567 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
EL062_RS16520 3600591..3601028 - 438 WP_004246810.1 D-tyrosyl-tRNA(Tyr) deacylase -
EL062_RS16525 3601109..3601726 - 618 WP_004246809.1 glucose-1-phosphatase -
EL062_RS16540 3602380..3602796 - 417 WP_049208252.1 hypothetical protein -
EL062_RS16545 3602774..3603097 - 324 WP_049208253.1 hypothetical protein -
EL062_RS16550 3603322..3603741 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
EL062_RS16555 3603738..3603971 - 234 WP_012368535.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL062_RS16560 3604722..3606557 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
EL062_RS16565 3606917..3608326 + 1410 WP_126402937.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T287028 WP_012368534.1 NZ_LR134205:c3603741-3603322 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT287028 WP_012368535.1 NZ_LR134205:c3603971-3603738 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References