Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3582750..3583449 Replicon chromosome
Accession NZ_LR134205
Organism Proteus mirabilis strain NCTC4199

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag EL062_RS16435 Protein ID WP_004249093.1
Coordinates 3582750..3583136 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag EL062_RS16440 Protein ID WP_004246828.1
Coordinates 3583129..3583449 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL062_RS16420 3578769..3579350 - 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -
EL062_RS16425 3579601..3580506 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
EL062_RS16430 3580516..3582588 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
EL062_RS16435 3582750..3583136 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL062_RS16440 3583129..3583449 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
EL062_RS16445 3583498..3583932 - 435 WP_004246827.1 hypothetical protein -
EL062_RS16450 3583925..3584809 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
EL062_RS16455 3585026..3586312 - 1287 WP_049196833.1 DUF3748 domain-containing protein -
EL062_RS16460 3586449..3587066 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
EL062_RS16465 3587368..3587991 + 624 WP_004246821.1 guanylate kinase -
EL062_RS16470 3588046..3588321 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T287027 WP_004249093.1 NZ_LR134205:3582750-3583136 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT287027 WP_004246828.1 NZ_LR134205:3583129-3583449 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References