Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3064146..3065167 Replicon chromosome
Accession NZ_LR134205
Organism Proteus mirabilis strain NCTC4199

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag EL062_RS14160 Protein ID WP_017827532.1
Coordinates 3064598..3065167 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag EL062_RS14155 Protein ID WP_004245528.1
Coordinates 3064146..3064598 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL062_RS14135 3059932..3060462 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
EL062_RS14140 3060731..3061744 + 1014 WP_004250228.1 thiamine ABC transporter substrate binding subunit -
EL062_RS14145 3061744..3063324 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
EL062_RS14150 3063317..3064018 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
EL062_RS14155 3064146..3064598 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
EL062_RS14160 3064598..3065167 + 570 WP_017827532.1 PIN domain-containing protein Toxin
EL062_RS14165 3065283..3067637 + 2355 WP_126402907.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T287026 WP_017827532.1 NZ_LR134205:3064598-3065167 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT287026 WP_004245528.1 NZ_LR134205:3064146-3064598 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References