Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1641675..1642265 Replicon chromosome
Accession NZ_LR134201
Organism Cedecea lapagei strain NCTC11466

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag EL098_RS07975 Protein ID WP_126355744.1
Coordinates 1641933..1642265 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag EL098_RS07970 Protein ID WP_126355743.1
Coordinates 1641675..1641932 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL098_RS07940 1637104..1637214 + 111 Protein_1529 PbsX family transcriptional regulator -
EL098_RS07945 1637270..1638064 + 795 WP_164716797.1 hypothetical protein -
EL098_RS07950 1638482..1639375 + 894 WP_126355741.1 hypothetical protein -
EL098_RS07955 1639426..1640544 + 1119 WP_126355742.1 threonine/serine transporter -
EL098_RS07960 1640548..1641348 - 801 WP_126358383.1 MBL fold metallo-hydrolase -
EL098_RS07965 1641433..1641625 + 193 Protein_1534 hypothetical protein -
EL098_RS07970 1641675..1641932 + 258 WP_126355743.1 antitoxin Antitoxin
EL098_RS07975 1641933..1642265 + 333 WP_126355744.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL098_RS07985 1642582..1643379 - 798 WP_126355745.1 DgsA anti-repressor MtfA -
EL098_RS07995 1643801..1644136 + 336 WP_126355746.1 multidrug DMT transporter -
EL098_RS08000 1644152..1645477 - 1326 WP_126355747.1 MFS transporter -
EL098_RS08005 1645515..1646784 - 1270 Protein_1540 MASE1 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11745.59 Da        Isoelectric Point: 10.1863

>T287019 WP_126355744.1 NZ_LR134201:1641933-1642265 [Cedecea lapagei]
MDRGEIWLVSLDPIAGHEQSGKFPVLIVSKASFNKLARLPVVVPVTSGGNFTRTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARSGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9495.06 Da        Isoelectric Point: 4.8227

>AT287019 WP_126355743.1 NZ_LR134201:1641675-1641932 [Cedecea lapagei]
MYKTRLKKVGGSIMLAVPPALLKTLKLTTDSEVSMTVDNGCLIIEPQKRPRYSLEELLAQCDPHAEISEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References