Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1094801..1095231 Replicon chromosome
Accession NZ_LR134201
Organism Cedecea lapagei strain NCTC11466

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL098_RS05400 Protein ID WP_126358358.1
Coordinates 1095064..1095231 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL098_RS05395 Protein ID WP_126355329.1
Coordinates 1094801..1095049 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL098_RS05365 1089986..1090336 - 351 WP_126355323.1 hypothetical protein -
EL098_RS05370 1090333..1090548 - 216 WP_126355324.1 helix-turn-helix transcriptional regulator -
EL098_RS05375 1090558..1091145 - 588 WP_126355325.1 hypothetical protein -
EL098_RS05380 1091431..1092075 + 645 WP_126355326.1 adenylate kinase -
EL098_RS05385 1092355..1093317 + 963 WP_126355327.1 ferrochelatase -
EL098_RS05390 1093381..1094685 + 1305 WP_126355328.1 inosine/guanosine kinase -
EL098_RS05395 1094801..1095049 + 249 WP_126355329.1 helix-turn-helix domain-containing protein Antitoxin
EL098_RS05400 1095064..1095231 + 168 WP_126358358.1 HipA domain-containing protein Toxin
EL098_RS23150 1095242..1095388 + 147 WP_164716779.1 type II toxin-antitoxin system HipA family toxin -
EL098_RS05405 1095426..1097102 - 1677 WP_126355330.1 Kef family K(+) transporter -
EL098_RS05410 1097320..1098537 - 1218 WP_126355331.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(1-51)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-61)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6525.68 Da        Isoelectric Point: 9.3532

>T287016 WP_126358358.1 NZ_LR134201:1095064-1095231 [Cedecea lapagei]
MQLAGLYGLKVPGCEIITTRNIKALAVERFDRRFVDNNRWIARLPQEDICQKMWF

Download         Length: 168 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9296.60 Da        Isoelectric Point: 8.6588

>AT287016 WP_126355329.1 NZ_LR134201:1094801-1095049 [Cedecea lapagei]
MKITSPEQLAIFLKDARKQGKQTQGAVAEKVGLRQDTVSKFENNPAKTQIDTLFKILSSMNMELHIETKSSQGSSEVWKE
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References