Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1063102..1063719 Replicon chromosome
Accession NZ_LR134201
Organism Cedecea lapagei strain NCTC11466

Toxin (Protein)


Gene name Hha Uniprot ID S3J5Z6
Locus tag EL098_RS05240 Protein ID WP_008460299.1
Coordinates 1063102..1063317 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X7LVC3
Locus tag EL098_RS05245 Protein ID WP_008460297.1
Coordinates 1063345..1063719 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL098_RS05215 1059274..1061178 + 1905 WP_126355298.1 methyl-accepting chemotaxis protein -
EL098_RS05220 1061303..1061563 + 261 WP_008460319.1 type B 50S ribosomal protein L31 -
EL098_RS05225 1061567..1061707 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL098_RS05230 1061711..1062187 - 477 WP_126355299.1 YlaC family protein -
EL098_RS05235 1062308..1062859 - 552 WP_126355300.1 maltose O-acetyltransferase -
EL098_RS05240 1063102..1063317 - 216 WP_008460299.1 hemolysin expression modulator Hha Toxin
EL098_RS05245 1063345..1063719 - 375 WP_008460297.1 Hha toxicity modulator TomB Antitoxin
EL098_RS05250 1064283..1067432 - 3150 WP_126355301.1 multidrug efflux RND transporter permease subunit AcrB -
EL098_RS05255 1067455..1068654 - 1200 WP_126355302.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8526.94 Da        Isoelectric Point: 9.4828

>T287015 WP_008460299.1 NZ_LR134201:c1063317-1063102 [Cedecea lapagei]
MTTKLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 216 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14459.17 Da        Isoelectric Point: 5.1574

>AT287015 WP_008460297.1 NZ_LR134201:c1063719-1063345 [Cedecea lapagei]
MDEYSPKRHDIAQLKFLCESLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAASALNYKIKYPDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQRWRKSGNRLFRCFISESRANPVSHSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X7LUT2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X7LVC3

References