Detailed information of TA system TA287011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 457592..458930
• Replicon: chromosome
• Accession: NZ_LR134201
• Organism: Cedecea lapagei strain NCTC11466

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: EL098_RS02325
• Protein ID: WP_126354478.1
• Coordinates: 457980..458930 (+)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: EL098_RS02320
• Protein ID: WP_088208768.1
• Coordinates: 457592..457987 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL098_RS02290	452650..453813	-	1164	WP_126354474.1	hypothetical protein	-
EL098_RS02295	454520..455338	+	819	Protein_436	DUF945 domain-containing protein	-
EL098_RS02300	455409..455879	+	471	WP_126354475.1	DNA repair protein RadC	-
EL098_RS02305	455892..456215	+	324	WP_126354476.1	type IV toxin-antitoxin system YeeU family antitoxin	-
EL098_RS02310	456258..456592	+	335	Protein_439	toxin	-
EL098_RS02315	456684..457517	+	834	WP_126354477.1	DUF4942 domain-containing protein	-
EL098_RS02320	457592..457987	+	396	WP_088208768.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EL098_RS02325	457980..458930	+	951	WP_126354478.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL098_RS02330	459175..459360	-	186	WP_126354479.1	helix-turn-helix domain-containing protein	-
EL098_RS02335	459455..460471	-	1017	WP_126354480.1	Gfo/Idh/MocA family oxidoreductase	-
EL098_RS02340	460483..461466	-	984	WP_126354481.1	PTS glucitol/sorbitol transporter subunit IIB	-
EL098_RS02345	461463..461837	-	375	WP_126354482.1	PTS sorbitol transporter	-
EL098_RS02350	461834..462367	-	534	WP_126354483.1	PTS glucitol/sorbitol transporter subunit IIC	-
EL098_RS02355	462502..462798	-	297	WP_126354484.1	helix-turn-helix domain-containing protein	-
EL098_RS02360	462970..463266	+	297	WP_126354485.1	helix-turn-helix domain-containing protein	-
EL098_RS02365	463267..463719	-	453	WP_126354486.1	N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-304)

Antitoxin

• Protein of unknown function DUF6088 (7-126)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 35894.46 Da
• Isoelectric Point: 4.8664

>T287011 WP_126354478.1 NZ_LR134201:457980-458930 [Cedecea lapagei]
MADLIKLFPDVADALGIESVAIVEKDYYIVELLRLLQPLAFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPIAGFSL
QYSRNQRKNIRKGIIKTITETIVASGMFSMDEEYPKVTSDENRYNEIPVRYPQKYAQAPCLRPFIKLELMETDLLEAAEN
RPISSLVMDLTKKGEVVRAFPCATIASTQAEKLISMMRRTAASMRNVERAVDESLVRHIYDNFCIVREKGADVPVLKHFV
QECIEQDIERYGVQYPEFCESPIGELKMGLEELVNNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Nucleotide

• Length: 951 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14439.83 Da
• Isoelectric Point: 11.0360

>AT287011 WP_088208768.1 NZ_LR134201:457592-457987 [Cedecea lapagei]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPALVEIKTSPRFKRTLSVGNSKLNG

Nucleotide

• Length: 396 bp