Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2504806..2506394 Replicon chromosome
Accession NZ_LR134196
Organism Klebsiella quasipneumoniae strain NCTC11357

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag EL110_RS12395 Protein ID WP_017900381.1
Coordinates 2504806..2506128 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag EL110_RS12400 Protein ID WP_004205921.1
Coordinates 2506128..2506394 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL110_RS12355 2499888..2500106 + 219 WP_002904808.1 ParD-like family protein -
EL110_RS12360 2500087..2500869 + 783 WP_049093365.1 type I methionyl aminopeptidase -
EL110_RS12365 2501138..2502253 + 1116 WP_049093366.1 serine hydrolase -
EL110_RS12370 2502240..2502584 + 345 WP_004205915.1 hypothetical protein -
EL110_RS12375 2502613..2503146 + 534 WP_053810394.1 hypothetical protein -
EL110_RS12380 2503149..2503355 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
EL110_RS12390 2503497..2504789 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
EL110_RS12395 2504806..2506128 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
EL110_RS12400 2506128..2506394 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL110_RS12405 2506677..2507003 - 327 WP_053810395.1 hydroxyisourate hydrolase -
EL110_RS12410 2507000..2507500 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
EL110_RS12415 2507478..2508857 - 1380 WP_017900377.1 purine permease -
EL110_RS12420 2509203..2510357 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
EL110_RS12425 2510338..2511261 - 924 WP_094311658.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T287008 WP_017900381.1 NZ_LR134196:c2506128-2504806 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT287008 WP_004205921.1 NZ_LR134196:c2506394-2506128 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References