Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 767130..767787 Replicon chromosome
Accession NZ_LR134196
Organism Klebsiella quasipneumoniae strain NCTC11357

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag EL110_RS03870 Protein ID WP_004205323.1
Coordinates 767377..767787 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EL110_RS03865 Protein ID WP_002916312.1
Coordinates 767130..767396 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL110_RS03840 762280..763713 - 1434 WP_080847486.1 6-phospho-beta-glucosidase BglA -
EL110_RS03845 763832..764560 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
EL110_RS03850 764611..764922 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EL110_RS03855 765085..765744 + 660 WP_004205319.1 hemolysin III family protein -
EL110_RS03860 765901..766884 - 984 WP_126494100.1 tRNA-modifying protein YgfZ -
EL110_RS03865 767130..767396 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EL110_RS03870 767377..767787 + 411 WP_004205323.1 protein YgfX Toxin
EL110_RS03875 767794..768315 - 522 WP_004205324.1 flavodoxin FldB -
EL110_RS03880 768416..769312 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EL110_RS03885 769335..770048 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL110_RS03890 770054..771787 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T287003 WP_004205323.1 NZ_LR134196:767377-767787 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT287003 WP_002916312.1 NZ_LR134196:767130-767396 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References